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 A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.

Miller BR, Gonzaga-Jauregui C, Brigatti KW, de Jong J, Breese RS, Ko SY, Puffenberger EG, Van Hout C, Young M, Luna VM, Staples J, First MB, Gregoire HJ, Dwork AJ, Pefanis E, McCarthy S, Brydges S, Rojas J, Ye B, Stahl E, Di Gioia SA, Hen R, Elwood K, Rosoklija G, Li D, Mellis S, Carey D, Croll SD, Overton JD, Macdonald LE, Economides AN, Shuldiner AR, Chuhma N, Rayport S, Amin N, Kushner SA, Alessandri-Haber N, Markx S, Strauss KA.Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2404754122. doi: 10.1073/pnas.2404754122. Epub 2025 Apr 14.PMID: 40228124

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 Transcriptomic and genetic analysis suggests a role for mitochondrial dysregulation in schizophrenia.

Bast L, Yao S, Martínez-López JA, Memic F, French H, Valiukonyte M, Karlsson R, Wen J, Song J, Zhang R, Abrantes A, Koopmans F, Österholm AM, Rosoklija G, Mann JJ, Stankov A, Trencevska I, Dwork A, Stockmeier CA, Love MI, Giusti-Rodriguez P, Smit AB, Sullivan PF, Hjerling-Leffler J.medRxiv [Preprint]. 2025 Mar 15:2025.03.14.25323827. doi: 10.1101/2025.03.14.25323827.PMID: 40162239 Free PMC article. Preprint.

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 A human brain map of mitochondrial respiratory capacity and diversity.

Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Junker A, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood MD, Boldrini M, Thiebaut de Schotten M, Picard M.Nature. 2025 Mar 26. doi: 10.1038/s41586-025-08740-6. Online ahead of print.PMID: 40140564​​

 

 Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples.

Chen Y, Chauhan S, Gong C, Dayton H, Xu C, De La Cruz ED, Tsai YW, Datta MS, Rosoklija GB, Dwork AJ, Mann JJ, Boldrini M, Leong KW, Dietrich LEP, Tomer R.Nat Biomed Eng. 2024 Sep;8(9):1109-1123. doi: 10.1038/s41551-024-01249-9. Epub 2024 Aug 29.PMID: 39209948​​

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Omics Approaches to Investigate the Pathogenesis of Suicide.

Boldrini M, Xiao Y, Singh T, Zhu C, Jabbi M, Pantazopoulos H, Gürsoy G, Martinowich K, Punzi G, Vallender EJ, Zody M, Berretta S, Hyde TM, Kleinman JE, Marenco S, Roussos P, Lewis DA, Turecki G, Lehner T, Mann JJ.Biol Psychiatry. 2024 Dec 15;96(12):919-928. doi: 10.1016/j.biopsych.2024.05.017. Epub 2024 May 29.PMID: 38821194

 

 Late-stage borreliosis and substance abuse.

Bransfield RC, Goud Gadila SK, Kursawe LJ, Dwork AJ, Rosoklija G, Horn EJ, Cook MJ, Embers ME.Heliyon. 2024 May 11;10(10):e31159. doi: 10.1016/j.heliyon.2024.e31159. eCollection 2024 May 30.PMID: 38779029 

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Brain and blood transcriptome profiles delineate common genetic pathways across suicidal ideation and suicide.

Sun S, Liu Q, Wang Z, Huang YY, Sublette ME, Dwork AJ, Rosoklija G, Ge Y, Galfalvy H, Mann JJ, Haghighi F.Mol Psychiatry. 2024 May;29(5):1417-1426. doi: 10.1038/s41380-024-02420-z. Epub 2024 Jan 26.PMID: 38278992 Free PMC article.

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 Reduced Bergmann glial process terminations and lateral appendages in essential tremor.

Ruff DS, Balbo I, Lai RY, Dieng D, Hennessey C, Vennam K, Dwork AJ, McCreary M, Louis ED, Faust PL, Kuo SH.Ann Clin Transl Neurol. 2024 Feb;11(2):377-388. doi: 10.1002/acn3.51958. Epub 2023 Dec 14.PMID: 38098226 Free PMC article.

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 Integrative transcriptome- and DNA methylation analysis of brain tissue from the temporal pole in suicide decedents and their controls.

Sha Q, Fu Z, Escobar Galvis ML, Madaj Z, Underwood MD, Steiner JA, Dwork A, Simpson N, Galfalvy H, Rozoklija G, Achtyes ED, Mann JJ, Brundin L.Mol Psychiatry. 2024 Jan;29(1):134-145. doi: 10.1038/s41380-023-02311-9. Epub 2023 Nov 8.PMID: 37938766 

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 Spatial epigenome-transcriptome co-profiling of mammalian tissues.

Zhang D, Deng Y, Kukanja P, Agirre E, Bartosovic M, Dong M, Ma C, Ma S, Su G, Bao S, Liu Y, Xiao Y, Rosoklija GB, Dwork AJ, Mann JJ, Leong KW, Boldrini M, Wang L, Haeussler M, Raphael BJ, Kluger Y, Castelo-Branco G, Fan R.Nature. 2023 Apr;616(7955):113-122. doi: 10.1038/s41586-023-05795-1. Epub 2023 Mar 15.PMID: 36922587 Free PMC article.

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 Electroconvulsive therapy-a shocking inducer of neuroplasticity?

Tartt AN, Mariani M, Hen R, Mann JJ, Boldrini M.Mol Psychiatry. 2024 Jan;29(1):35-37. doi: 10.1038/s41380-023-02015-0. Epub 2023 Mar 3.PMID: 36869226 No abstract available.

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 In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity.

Bartlett EA, Yttredahl AA, Boldrini M, Tyrer AE, Hill KR, Ananth MR, Milak MS, Oquendo MA, Mann JJ, DeLorenzo C, Parsey RV.Eur Psychiatry. 2023 Jan 24;66(1):e17. doi: 10.1192/j.eurpsy.2023.4.PMID: 36691786